On November 4-5, 2021, the ICT research and entrepreneurship conference “ICT Means Business” took place on-site at the University of Tartu Delta Centre and online. At the conference, 30 researchers from the University of Tartu, TalTech and Tallinn University gave an overview of the “hot” frontier research areas, development trends and state-of-the-art technologies in ICT. They also introduced collaboration opportunities with the public and business sector. The conference was organised in cooperation with the University of Tartu, TalTech, Tallinn University, ITL, the Ministry of Education and Research and the Education and Youth Board as the coordinator of the IT Academy program. The conference was supported by the European Social Fund.